Deficits in Endogenous Adenosine Formation by Ecto-5′-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis

AMP dephosphorylation via ecto-5′-nucleotidase/CD73 is the rate limiting step to generate extracellular adenosine (ADO) from released adenine nucleotides. ADO, via A(2A) receptors (A(2A)Rs), is a potent modulator of neuromuscular and immunological responses. The pivotal role of ecto-5′-nucleotidase/...

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Bibliographic Details
Published in:Mediators Inflamm
Main Authors: Oliveira, Laura, Correia, Alexandra, Cristina Costa, Ana, Guerra-Gomes, Sónia, Ferreirinha, Fátima, Magalhães-Cardoso, Maria Teresa, Vilanova, Manuel, Correia-de-Sá, Paulo
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322825/
https://ncbi.nlm.nih.gov/pubmed/25691808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/460610
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