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Deficits in Endogenous Adenosine Formation by Ecto-5′-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis
AMP dephosphorylation via ecto-5′-nucleotidase/CD73 is the rate limiting step to generate extracellular adenosine (ADO) from released adenine nucleotides. ADO, via A(2A) receptors (A(2A)Rs), is a potent modulator of neuromuscular and immunological responses. The pivotal role of ecto-5′-nucleotidase/...
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| Publicado no: | Mediators Inflamm |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Publishing Corporation
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4322825/ https://ncbi.nlm.nih.gov/pubmed/25691808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/460610 |
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