Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells

Immune dysregulation drives the pathogenesis of chronic inflammatory, autoimmune and dysplastic disorders. While often intended to address localized pathology, most immune modulatory therapies are administered systemically and carry inherent risk of multi-organ toxicities. Here we demonstrate, in a...

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Foilsithe in:Cancer Res
Main Authors: Chung, Allen Y., Li, Qingsheng, Blair, Sarah J., De Jesus, Magdia, Dennis, Kristen L., LeVea, Charles, Yao, Jin, Sun, Yijun, Conway, Thomas F., Virtuoso, Lauren P., Battaglia, Nicholas G., Furtado, Stacia, Mathiowitz, Edith, Mantis, Nicholas J., Khazaie, Khashayarsha, Egilmez, Nejat K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322772/
https://ncbi.nlm.nih.gov/pubmed/25228656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0918
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