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The Use of Pharmacological Retromer Chaperones in Alzheimer’s Disease and other Endosomal-related Disorders
The retromer is an evolutionary conserved multiprotein complex involved in the sorting and retrograde trafficking of cargo from endosomal compartments to the Golgi network and to the cell surface. The neuronal retromer traffics the amyloid precursor protein away from the endosomes, a site where amyl...
Enregistré dans:
| Publié dans: | Neurotherapeutics |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Springer US
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4322078/ https://ncbi.nlm.nih.gov/pubmed/25472693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-014-0321-y |
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