Tau and other proteins found in Alzheimer’s disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans

Endosomal trafficking has emerged as a defective biological pathway in Alzheimer’s disease (AD), and the pathway is a source of cerebrospinal fluid (CSF) protein accumulation. Nevertheless, the identity of the CSF proteins that accumulate in the setting of defects in AD’s endosomal trafficking pathw...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Simoes, Sabrina, Neufeld, Jessica L., Triana-Baltzer, Gallen, Moughadam, Setareh, Chen, Emily I., Kothiya, Milankumar, Qureshi, Yasir H., Patel, Vivek, Honig, Lawrence S., Kolb, Hartmuth, Small, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901670/
https://ncbi.nlm.nih.gov/pubmed/33239387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aba6334
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