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The Use of Pharmacological Retromer Chaperones in Alzheimer’s Disease and other Endosomal-related Disorders

The retromer is an evolutionary conserved multiprotein complex involved in the sorting and retrograde trafficking of cargo from endosomal compartments to the Golgi network and to the cell surface. The neuronal retromer traffics the amyloid precursor protein away from the endosomes, a site where amyl...

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Bibliografske podrobnosti
izdano v:Neurotherapeutics
Main Authors: Berman, Diego E., Ringe, Dagmar, Petsko, Greg A., Small, Scott A.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322078/
https://ncbi.nlm.nih.gov/pubmed/25472693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-014-0321-y
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