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Synthesis of 13,14-dehydroprostacyclin methyl ester: a potent inhibitor of platelet aggregation.
The structure of the most recently discovered, biologically highly active prostaglandin, PGI2 or prostacyclin, is correctly predicted on biogenetic grounds, and a general synthesis starting with prostaglandins of the F2alpha series is reported. Starting with the biologically active 13,14-dehydro-PGF...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1977
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC432136/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/267919/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.6.2199 |
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