Synthesis and biological properties of a 9,11-azo-prostanoid: highly active biochemical mimic of prostaglandin endoperoxides.

The 9,11-azo-prostanoid III [(5Z, 9alpha, 11alpha, 13E, 15S)-9, 11-azo-15-hydroxyprosta-5,13-dienoic acid] has been obtained by synthesis and tested for biological activity in systems which are responsive to the prostaglandin endoperoxides PGH2 (I) and PGG2 (II). The azo analog III is a powerful mim...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Corey, E J, Nicolaou, K C, Machida, Y, Malmsten, C L, Samuelsson, B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1975
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC432991/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1059121/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.72.9.3355
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