Hemoglobin switching in sheep and goats: induction of hemoglobin C synthesis in cultures of sheep fetal erythroid cells.

Synthesis of HbF (alpha2gamma2) is replaced by synthesis of Hb A (alpha2betaA2) shortly before birth in sheep homozygous for the betaA globin chain whereas Hb C (alpha2betaC2) is produced transiently during the neonatal period. We have obtained a Hb F-to-Hb C switch by generating erythroid colonies...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Barker, J E, Pierce, J E, Kefauver, B C, Nienhuis, A W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1977
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC432102/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/270742/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.11.5078
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