Hemoglobin switching in sheep and goats: induction of hemoglobin C synthesis in cultures of sheep fetal erythroid cells.

Synthesis of HbF (alpha2gamma2) is replaced by synthesis of Hb A (alpha2betaA2) shortly before birth in sheep homozygous for the betaA globin chain whereas Hb C (alpha2betaC2) is produced transiently during the neonatal period. We have obtained a Hb F-to-Hb C switch by generating erythroid colonies...

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Main Authors: Barker, J E, Pierce, J E, Kefauver, B C, Nienhuis, A W
Format: Artigo
Sprog:Inglês
Udgivet: 1977
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC432102/
https://ncbi.nlm.nih.gov/pubmed/270742
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