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Hemoglobin switching in sheep: Only the γ gene is in the active conformation in fetal liver but all the β and γ genes are in the active conformation in bone marrow

Differential expression of the closely linked γ, β(A) (or β(B)), and β(C) globin genes in sheep results in the production of fetal hemoglobin (Hb F, α(2)γ(2)) during gestation and the adult hemoglobins (Hb A, α(2)β(2)(A), and Hb B, α(2)β(2)(B)) after birth. Erythropoietic stress in certain animals l...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Young, Neal S., Benz, Edward J., Kantor, Judith A., Kretschmer, Peter, Nienhuis, Arthur W.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 1978
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393080/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/282609/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.12.5884
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