Hemoglobin switching in sheep: Only the γ gene is in the active conformation in fetal liver but all the β and γ genes are in the active conformation in bone marrow

Differential expression of the closely linked γ, β(A) (or β(B)), and β(C) globin genes in sheep results in the production of fetal hemoglobin (Hb F, α(2)γ(2)) during gestation and the adult hemoglobins (Hb A, α(2)β(2)(A), and Hb B, α(2)β(2)(B)) after birth. Erythropoietic stress in certain animals l...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Young, Neal S., Benz, Edward J., Kantor, Judith A., Kretschmer, Peter, Nienhuis, Arthur W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1978
Assuntos:	Biological Sciences: Biochemistry
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393080/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/282609/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.12.5884
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