Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice

OBJECTIVES: An imbalance between neutrophil extracellular trap (NET) formation and degradation has been described in systemic lupus erythematosus (SLE), potentially contributing to autoantigen externalisation, type I interferon synthesis and endothelial damage. We have demonstrated that peptidylargi...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Knight, Jason S., Subramanian, Venkataraman, O’Dell, Alexander A., Yalavarthi, Srilakshmi, Zhao, Wenpu, Smith, Carolyne K., Hodgin, Jeffrey B., Thompson, Paul R., Kaplan, Mariana J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320672/
https://ncbi.nlm.nih.gov/pubmed/25104775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-205365
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