Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

RATIONALE: Neutrophil extracellular trap (NET) formation promotes vascular damage, thrombosis, and activation of interferon-α-producing plasmacytoid dendritic cells in diseased arteries. Peptidylarginine deiminase inhibition is a strategy that can decrease in vivo NET formation. OBJECTIVE: To test w...

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Main Authors: Knight, Jason S., Luo, Wei, O’Dell, Alexander A., Yalavarthi, Srilakshmi, Zhao, Wenpu, Subramanian, Venkataraman, Guo, Chiao, Grenn, Robert C., Thompson, Paul R., Eitzman, Daniel T., Kaplan, Mariana J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185401/
https://ncbi.nlm.nih.gov/pubmed/24425713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.303312
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