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PI3′-Kinase Inhibition Forestalls the Onset of MEK1/2 Inhibitor Resistance in BRAF-Mutated Melanoma

Phosphatidylinositide 3′ (PI3′)-lipid signaling cooperates with oncogenic BRAF(V600E) to promote melanomagenesis. Sustained PI3′-lipid production commonly occurs via silencing of the PI3′-lipid phosphatase PTEN or, less commonly, through mutational activation of PIK3CA, encoding the 110kDa catalytic...

詳細記述

保存先:
書誌詳細
出版年:Cancer Discov
主要な著者: Deuker, Marian M., Durban, Victoria Marsh, Phillips, Wayne A., McMahon, Martin
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320669/
https://ncbi.nlm.nih.gov/pubmed/25472943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0856
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