A B cell follicle sanctuary permits persistent productive SIV infection in elite controllers

Chronic phase HIV/SIV replication is reduced by as much as 10,000-fold in elite controllers (EC) compared to typical progressors, but sufficient viral replication persists in EC tissues to allow viral sequence evolution and induce excess immune activation. Here, we show that productive SIV infection...

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Udgivet i:Nat Med
Main Authors: Fukazawa, Yoshinori, Lum, Richard, Okoye, Afam A., Park, Haesun, Matsuda, Kenta, Bae, Jin Young, Hagen, Shoko I., Shoemaker, Rebecca, Deleage, Claire, Lucero, Carissa, Morcock, David, Swanson, Tonya, Legasse, Alfred W., Axthelm, Michael K., Hesselgesser, Joseph, Geleziunas, Romas, Hirsch, Vanessa M., Edlefsen, Paul T., Piatak, Michael, Estes, Jacob D., Lifson, Jeffrey D., Picker, Louis J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320022/
https://ncbi.nlm.nih.gov/pubmed/25599132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3781
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