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Clinically relevant fluoroquinolone resistance due to constitutive overexpression of the PatAB ABC transporter in Streptococcus pneumoniae is conferred by disruption of a transcriptional attenuator

OBJECTIVES: Constitutive overexpression of patAB has been observed in several unrelated fluoroquinolone-resistant laboratory mutants and clinical isolates; therefore, we sought to identify the cause of this overexpression. METHODS: Constitutive patAB overexpression in two clinical isolates and a lab...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Baylay, Alison J., Piddock, Laura J. V.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319486/
https://ncbi.nlm.nih.gov/pubmed/25411187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku449
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