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Inhibited Insulin Signaling in Mouse Hepatocytes Is Associated with Increased Phosphatidic Acid but Not Diacylglycerol

Although an elevated triacylglycerol content in non-adipose tissues is often associated with insulin resistance, the mechanistic relationship remains unclear. The data support roles for intermediates in the glycerol-3-phosphate pathway of triacylglycerol synthesis: diacylglycerol (DAG), which may ca...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Zhang, Chongben, Hwarng, Gwen, Cooper, Daniel E., Grevengoed, Trisha J., Eaton, James M., Natarajan, Viswanathan, Harris, Thurl E., Coleman, Rosalind A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319019/
https://ncbi.nlm.nih.gov/pubmed/25512376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.602789
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