SorLA Complement-type Repeat Domains Protect the Amyloid Precursor Protein against Processing

SorLA is a neuronal sorting receptor that is genetically associated with Alzheimer disease. SorLA interacts directly with the amyloid precursor protein (APP) and affects the processing of the precursor, leading to a decreased generation of the amyloid-β peptide. The SorLA complement-type repeat (CR)...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Mehmedbasic, Arnela, Christensen, Sofie K., Nilsson, Jonas, Rüetschi, Ulla, Gustafsen, Camilla, Poulsen, Annemarie Svane Aavild, Rasmussen, Rikke W., Fjorback, Anja N., Larson, Göran, Andersen, Olav M.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2015
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319007/
https://ncbi.nlm.nih.gov/pubmed/25525276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.619940
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