Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein

The development and progression of Alzheimer's disease is linked to excessive production of toxic amyloid-β peptide, initiated by β-secretase cleavage of the amyloid precursor protein (APP). In contrast, soluble APPα (sAPPα) generated by the α-secretase is known to stimulate dendritic branching...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Gustafsen, Camilla, Glerup, Simon, Pallesen, Lone Tjener, Olsen, Ditte, Andersen, Olav M., Nykjær, Anders, Madsen, Peder, Petersen, Claus Munck
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2013
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Brief Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618638/
https://ncbi.nlm.nih.gov/pubmed/23283322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2371-12.2013
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