Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys

Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of infection. In response to this largely unmet need for...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Thuita, John K., Wolf, Kristina K., Murilla, Grace A., Bridges, Arlene S., Boykin, David W., Mutuku, James N., Liu, Qiang, Jones, Susan K., Gem, Charles O., Ching, Shelley, Tidwell, Richard R., Wang, Michael Z., Paine, Mary F., Brun, Reto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318582/
https://ncbi.nlm.nih.gov/pubmed/25654243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003409
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