Pharmacology of DB844, an Orally Active aza Analogue of Pafuramidine, in a Monkey Model of Second Stage Human African Trypanosomiasis

Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite the recent addition of nifurtimox-eflornithine combination therapy (NECT) to WHO Model Lists of Essential Medicines against second stage HAT, where parasites have invaded the central nervous system (CNS). The...

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Main Authors: Thuita, John K., Wang, Michael Z., Kagira, John M., Denton, Cathrine L., Paine, Mary F., Mdachi, Raymond E., Murilla, Grace A., Ching, Shelley, Boykin, David W., Tidwell, Richard R., Hall, James E., Brun, Reto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404106/
https://ncbi.nlm.nih.gov/pubmed/22848769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001734
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