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Natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1
Helicobacter pylori strains carrying the cagA gene are associated with severe disease outcomes, most notably gastric cancer. CagA protein is delivered into gastric epithelial cells by a type IV secretion system. The translocated CagA undergoes tyrosine phosphorylation at the C-terminal EPIYA motifs...
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| Publicado no: | Cancer Sci |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4317943/ https://ncbi.nlm.nih.gov/pubmed/24354359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12342 |
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