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Helicobacter pylori CagA Causes Mitotic Impairment and Induces Chromosomal Instability

Infection with cagA-positive Helicobacter pylori is the strongest risk factor for the development of gastric carcinoma. The cagA gene product CagA, which is delivered into gastric epithelial cells, specifically binds to and aberrantly activates SHP-2 oncoprotein. CagA also interacts with and inhibit...

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Detalhes bibliográficos
Main Authors: Umeda, Mayumi, Murata-Kamiya, Naoko, Saito, Yasuhiro, Ohba, Yusuke, Takahashi, Masayuki, Hatakeyama, Masanori
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755941/
https://ncbi.nlm.nih.gov/pubmed/19546211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.035766
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