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Helicobacter pylori CagA Causes Mitotic Impairment and Induces Chromosomal Instability

Infection with cagA-positive Helicobacter pylori is the strongest risk factor for the development of gastric carcinoma. The cagA gene product CagA, which is delivered into gastric epithelial cells, specifically binds to and aberrantly activates SHP-2 oncoprotein. CagA also interacts with and inhibit...

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Autori principali: Umeda, Mayumi, Murata-Kamiya, Naoko, Saito, Yasuhiro, Ohba, Yusuke, Takahashi, Masayuki, Hatakeyama, Masanori
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755941/
https://ncbi.nlm.nih.gov/pubmed/19546211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.035766
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