Helicobacter pylori CagA Causes Mitotic Impairment and Induces Chromosomal Instability

Infection with cagA-positive Helicobacter pylori is the strongest risk factor for the development of gastric carcinoma. The cagA gene product CagA, which is delivered into gastric epithelial cells, specifically binds to and aberrantly activates SHP-2 oncoprotein. CagA also interacts with and inhibit...

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Autors principals: Umeda, Mayumi, Murata-Kamiya, Naoko, Saito, Yasuhiro, Ohba, Yusuke, Takahashi, Masayuki, Hatakeyama, Masanori
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Mechanisms of Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755941/
https://ncbi.nlm.nih.gov/pubmed/19546211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.035766
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