Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells.

Cultured endothelial cells derived from human umbilical veins or bovine aorta produce a potent inhibitor of platelet aggregation. The inhibitor is synthesized from sodium arachidonate or or prostaglandin endoperoxides by a microsomal enzyme system. Tranylcypromine, a specific antagonist of prostacyc...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Weksler, B B, Marcus, A J, Jaffe, E A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1977
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/333448/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.9.3922
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