Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells

Mice deficient in the nuclear hormone receptor RORγt have defective development of thymocytes, lymphoid organs, Th17 cells and type 3 innate lymphoid cells. RORγt binds to oxysterols derived from cholesterol catabolism but it is not clear whether these are its natural ligands. Here, we show that ste...

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Bibliographic Details
Published in:Cell Metab
Main Authors: Santori, Fabio R., Huang, Pengxiang, van de Pavert, Serge A., Douglass, Eugene F., Leaver, David J., Haubrich, Brad A., Keber, Rok, Lorbek, Gregor, Konijn, Tanja, Rosales, Brittany N., Horvat, Simon, Rozman, Damjana, Rahier, Alain, Mebius, Reina E., Rastinejad, Fraydoon, Nes, W. David, Littman, Dan R.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317570/
https://ncbi.nlm.nih.gov/pubmed/25651181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.01.004
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