Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors

[Image: see text] Retinoic acid-related orphan receptor RORγt plays a pivotal role in the differentiation of T(H)17 cells. Antagonizing RORγt transcriptional activity is a potential means to treat T(H)17-related autoimmune diseases. Herein, we describe the identification of a series of diphenylpropa...

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Detalhes bibliográficos
Main Authors: Huh, Jun R., Englund, Erika E., Wang, Hang, Huang, Ruili, Huang, Pengxiang, Rastinejad, Fraydoon, Inglese, James, Austin, Christopher P., Johnson, Ronald L., Huang, Wenwei, Littman, Dan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770298/
https://ncbi.nlm.nih.gov/pubmed/24040486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300286h
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