Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells

Mice deficient in the nuclear hormone receptor RORγt have defective development of thymocytes, lymphoid organs, Th17 cells and type 3 innate lymphoid cells. RORγt binds to oxysterols derived from cholesterol catabolism but it is not clear whether these are its natural ligands. Here, we show that ste...

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Bibliografiske detaljer
Udgivet i:Cell Metab
Main Authors: Santori, Fabio R., Huang, Pengxiang, van de Pavert, Serge A., Douglass, Eugene F., Leaver, David J., Haubrich, Brad A., Keber, Rok, Lorbek, Gregor, Konijn, Tanja, Rosales, Brittany N., Horvat, Simon, Rozman, Damjana, Rahier, Alain, Mebius, Reina E., Rastinejad, Fraydoon, Nes, W. David, Littman, Dan R.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317570/
https://ncbi.nlm.nih.gov/pubmed/25651181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.01.004
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