Hidden disease susceptibility and sexual dimorphism in the heterozygous knockout of Cyp51 from cholesterol synthesis.

We examined the genotype-phenotype interactions of Cyp51+/- mice carrying one functional allele of lanosterol 14α-demethylase from cholesterol biosynthesis. No distinct developmental or morphological abnormalities were observed by routine visual inspection of Cyp51+/- and Cyp51+/+ mice and fertility...

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Bibliographic Details
Main Authors: Monika Lewinska, Peter Juvan, Martina Perse, Jera Jeruc, Spela Kos, Gregor Lorbek, Ziga Urlep, Rok Keber, Simon Horvat, Damjana Rozman
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4231084?pdf=render
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