Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury

We demonstrate unequivocally that defective cholesterol synthesis is an independent determinant of liver inflammation and fibrosis. We prepared a mouse hepatocyte-specific knockout (LKO) of lanosterol 14α-demethylase (CYP51) from the part of cholesterol synthesis that is already committed to cholest...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lorbek, Gregor, Perše, Martina, Jeruc, Jera, Juvan, Peter, Gutierrez-Mariscal, Francisco M., Lewinska, Monika, Gebhardt, Rolf, Keber, Rok, Horvat, Simon, Björkhem, Ingemar, Rozman, Damjana
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350092/
https://ncbi.nlm.nih.gov/pubmed/25739789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08777
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados