Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury

We demonstrate unequivocally that defective cholesterol synthesis is an independent determinant of liver inflammation and fibrosis. We prepared a mouse hepatocyte-specific knockout (LKO) of lanosterol 14α-demethylase (CYP51) from the part of cholesterol synthesis that is already committed to cholest...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Lorbek, Gregor, Perše, Martina, Jeruc, Jera, Juvan, Peter, Gutierrez-Mariscal, Francisco M., Lewinska, Monika, Gebhardt, Rolf, Keber, Rok, Horvat, Simon, Björkhem, Ingemar, Rozman, Damjana
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350092/
https://ncbi.nlm.nih.gov/pubmed/25739789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08777
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы