A novel aminoacid determinant of HIV-1 restriction in the TRIM5α variable 1 region isolated in a random mutagenic screen

Human-derived antiretroviral transgenes are of great biomedical interest and are actively pursued. HIV-1 is efficiently inhibited at post-entry, pre-integration replication stages by point mutations in the variable region 1 (v1) of the human restriction factor TRIM5α. Here we use a mutated megaprime...

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Détails bibliographiques
Publié dans:Virus Res
Auteurs principaux: Pham, Quang Toan, Veillette, Maxime, Brandariz-Nuñez, Alberto, Pawlica, Paulina, Thibert-Lefebvre, Caroline, Chandonnet, Nadia, Diaz-Griffero, Felipe, Berthoux, Lionel
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317569/
https://ncbi.nlm.nih.gov/pubmed/23357295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2013.01.013
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