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Alzheimer’s Protective A2T Mutation Changes the Conformational Landscape of the Aβ(1–42) Monomer Differently Than Does the A2V Mutation
The aggregation of amyloid-β (Aβ) peptides plays a crucial role in the etiology of Alzheimer’s disease (AD). Recently, it has been reported that an A2T mutation in Aβ can protect against AD. Interestingly, a nonpolar A2V mutation also has been found to offer protection against AD in the heterozygous...
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| Gepubliceerd in: | Biophys J |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The Biophysical Society
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4317528/ https://ncbi.nlm.nih.gov/pubmed/25650940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.12.013 |
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