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Effect of Proline Mutations on the Monomer Conformations of Amylin
The formation of human islet amyloid polypeptide (hIAPP) is implicated in the loss of pancreatic β-cells in type II diabetes. Rat amylin, which differs from human amylin at six residues, does not lead to formation of amyloid fibrils. Pramlintide is a synthetic analog of human amylin that shares thre...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Biophysical Society
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3762349/ https://ncbi.nlm.nih.gov/pubmed/24010666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.07.029 |
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