p53 Degradation by a Coronavirus Papain-like Protease Suppresses Type I Interferon Signaling

Infection by human coronaviruses is usually characterized by rampant viral replication and severe immunopathology in host cells. Recently, the coronavirus papain-like proteases (PLPs) have been identified as suppressors of the innate immune response. However, the molecular mechanism of this inhibiti...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Yuan, Lin, Chen, Zhongbin, Song, Shanshan, Wang, Shan, Tian, Chunyan, Xing, Guichun, Chen, Xiaojuan, Xiao, Zhi-Xiong, He, Fuchu, Zhang, Lingqiang
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317044/
https://ncbi.nlm.nih.gov/pubmed/25505178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.619890
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