The dehydrogenase region of the NADPH oxidase component Nox2 acts as a protein disulfide isomerase (PDI) resembling PDIA3 with a role in the binding of the activator protein p67(phox)

The superoxide (O(·−)(2))-generating NADPH oxidase of phagocytes consists of a membrane component, cytochrome b(558) (a heterodimer of Nox2 and p22(phox)), and four cytosolic components, p47(phox), p67(phox), p40(phox), and Rac. The catalytic component, responsible for O(·−)(2) generation, is Nox2....

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Bechor, Edna, Dahan, Iris, Fradin, Tanya, Berdichevsky, Yevgeny, Zahavi, Anat, Federman Gross, Aya, Rafalowski, Meirav, Pick, Edgar
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4316792/
https://ncbi.nlm.nih.gov/pubmed/25699251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2015.00003
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