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Compartmentalization of GABA Synthesis by GAD67 Differs between Pancreatic Beta Cells and Neurons

The inhibitory neurotransmitter GABA is synthesized by the enzyme glutamic acid decarboxylase (GAD) in neurons and in pancreatic β-cells in islets of Langerhans where it functions as a paracrine and autocrine signaling molecule regulating the function of islet endocrine cells. The localization of th...

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Pubblicato in:PLoS One
Autori principali: Kanaani, Jamil, Cianciaruso, Chiara, Phelps, Edward A., Pasquier, Miriella, Brioudes, Estelle, Billestrup, Nils, Baekkeskov, Steinunn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315522/
https://ncbi.nlm.nih.gov/pubmed/25647668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117130
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