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Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial

The RV144 clinical trial showed the partial efficacy of a vaccine regimen with an estimated vaccine efficacy (VE) of 31% for protecting low-risk Thai volunteers against acquisition of HIV-1. The impact of vaccine-induced immune responses can be investigated through sieve analysis of HIV-1 breakthrou...

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Gepubliceerd in:PLoS Comput Biol
Hoofdauteurs: Edlefsen, Paul T., Rolland, Morgane, Hertz, Tomer, Tovanabutra, Sodsai, Gartland, Andrew J., deCamp, Allan C., Magaret, Craig A., Ahmed, Hasan, Gottardo, Raphael, Juraska, Michal, McCoy, Connor, Larsen, Brendan B., Sanders-Buell, Eric, Carrico, Chris, Menis, Sergey, Bose, Meera, Arroyo, Miguel A., O’Connell, Robert J., Nitayaphan, Sorachai, Pitisuttithum, Punnee, Kaewkungwal, Jaranit, Rerks-Ngarm, Supachai, Robb, Merlin L., Kirys, Tatsiana, Georgiev, Ivelin S., Kwong, Peter D., Scheffler, Konrad, Pond, Sergei L. Kosakovsky, Carlson, Jonathan M., Michael, Nelson L., Schief, William R., Mullins, James I., Kim, Jerome H., Gilbert, Peter B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315437/
https://ncbi.nlm.nih.gov/pubmed/25646817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003973
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