Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial

The RV144 clinical trial showed the partial efficacy of a vaccine regimen with an estimated vaccine efficacy (VE) of 31% for protecting low-risk Thai volunteers against acquisition of HIV-1. The impact of vaccine-induced immune responses can be investigated through sieve analysis of HIV-1 breakthrou...

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Publicat a:PLoS Comput Biol
Autors principals: Edlefsen, Paul T., Rolland, Morgane, Hertz, Tomer, Tovanabutra, Sodsai, Gartland, Andrew J., deCamp, Allan C., Magaret, Craig A., Ahmed, Hasan, Gottardo, Raphael, Juraska, Michal, McCoy, Connor, Larsen, Brendan B., Sanders-Buell, Eric, Carrico, Chris, Menis, Sergey, Bose, Meera, Arroyo, Miguel A., O’Connell, Robert J., Nitayaphan, Sorachai, Pitisuttithum, Punnee, Kaewkungwal, Jaranit, Rerks-Ngarm, Supachai, Robb, Merlin L., Kirys, Tatsiana, Georgiev, Ivelin S., Kwong, Peter D., Scheffler, Konrad, Pond, Sergei L. Kosakovsky, Carlson, Jonathan M., Michael, Nelson L., Schief, William R., Mullins, James I., Kim, Jerome H., Gilbert, Peter B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315437/
https://ncbi.nlm.nih.gov/pubmed/25646817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003973
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