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Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial

The RV144 clinical trial showed the partial efficacy of a vaccine regimen with an estimated vaccine efficacy (VE) of 31% for protecting low-risk Thai volunteers against acquisition of HIV-1. The impact of vaccine-induced immune responses can be investigated through sieve analysis of HIV-1 breakthrou...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Edlefsen, Paul T., Rolland, Morgane, Hertz, Tomer, Tovanabutra, Sodsai, Gartland, Andrew J., deCamp, Allan C., Magaret, Craig A., Ahmed, Hasan, Gottardo, Raphael, Juraska, Michal, McCoy, Connor, Larsen, Brendan B., Sanders-Buell, Eric, Carrico, Chris, Menis, Sergey, Bose, Meera, Arroyo, Miguel A., O’Connell, Robert J., Nitayaphan, Sorachai, Pitisuttithum, Punnee, Kaewkungwal, Jaranit, Rerks-Ngarm, Supachai, Robb, Merlin L., Kirys, Tatsiana, Georgiev, Ivelin S., Kwong, Peter D., Scheffler, Konrad, Pond, Sergei L. Kosakovsky, Carlson, Jonathan M., Michael, Nelson L., Schief, William R., Mullins, James I., Kim, Jerome H., Gilbert, Peter B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315437/
https://ncbi.nlm.nih.gov/pubmed/25646817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003973
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