Anti-Lubricin Monoclonal Antibodies Created Using Lubricin-Knockout Mice Immunodetect Lubricin in Several Species and in Patients with Healthy and Diseased Joints

Lubricin, encoded by the gene PRG4, is the principal lubricant in articulating joints. We immunized mice genetically deficient for lubricin (Prg4-/-) with purified human lubricin, and generated several mAbs. We determined each mAb’s binding epitope, sensitivity, and specificity using biologic sample...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Ai, Minrong, Cui, Yajun, Sy, Man-Sun, Lee, David M., Zhang, Ling Xiu, Larson, Katherine M., Kurek, Kyle C., Jay, Gregory D., Warman, Matthew L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314068/
https://ncbi.nlm.nih.gov/pubmed/25642942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116237
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