Anti-Lubricin Monoclonal Antibodies Created Using Lubricin-Knockout Mice Immunodetect Lubricin in Several Species and in Patients with Healthy and Diseased Joints

Lubricin, encoded by the gene PRG4, is the principal lubricant in articulating joints. We immunized mice genetically deficient for lubricin (Prg4-/-) with purified human lubricin, and generated several mAbs. We determined each mAb’s binding epitope, sensitivity, and specificity using biologic sample...

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Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Ai, Minrong, Cui, Yajun, Sy, Man-Sun, Lee, David M., Zhang, Ling Xiu, Larson, Katherine M., Kurek, Kyle C., Jay, Gregory D., Warman, Matthew L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314068/
https://ncbi.nlm.nih.gov/pubmed/25642942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116237
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