Anti-Lubricin Monoclonal Antibodies Created Using Lubricin-Knockout Mice Immunodetect Lubricin in Several Species and in Patients with Healthy and Diseased Joints

Lubricin, encoded by the gene PRG4, is the principal lubricant in articulating joints. We immunized mice genetically deficient for lubricin (Prg4-/-) with purified human lubricin, and generated several mAbs. We determined each mAb’s binding epitope, sensitivity, and specificity using biologic sample...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ai, Minrong, Cui, Yajun, Sy, Man-Sun, Lee, David M., Zhang, Ling Xiu, Larson, Katherine M., Kurek, Kyle C., Jay, Gregory D., Warman, Matthew L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314068/
https://ncbi.nlm.nih.gov/pubmed/25642942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116237
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