Kinin B1 receptor antagonism is equally efficient as angiotensin receptor 1 antagonism in reducing renal fibrosis in experimental obstructive nephropathy, but is not additive

Background: Renal tubulointerstitial fibrosis is the pathological hallmark of chronic kidney disease (CKD). Currently, inhibitors of the renin–angiotensin system (RAS) remain the sole therapy in human displaying antifibrotic properties. Further antifibrotic molecules are needed. We have recently rep...

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Udgivet i:Front Pharmacol
Main Authors: Huart, Antoine, Klein, Julie, Gonzalez, Julien, Buffin-Meyer, Bénédicte, Neau, Eric, Delage, Christine, Calise, Denis, Ribes, David, Schanstra, Joost P., Bascands, Jean-Loup
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313587/
https://ncbi.nlm.nih.gov/pubmed/25698969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00008
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