Kinin B1 receptor antagonism is equally efficient as angiotensin receptor 1 antagonism in reducing renal fibrosis in experimental obstructive nephropathy, but is not additive

Background: Renal tubulointerstitial fibrosis is the pathological hallmark of chronic kidney disease (CKD). Currently, inhibitors of the renin–angiotensin system (RAS) remain the sole therapy in human displaying antifibrotic properties. Further antifibrotic molecules are needed. We have recently rep...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Huart, Antoine, Klein, Julie, Gonzalez, Julien, Buffin-Meyer, Bénédicte, Neau, Eric, Delage, Christine, Calise, Denis, Ribes, David, Schanstra, Joost P., Bascands, Jean-Loup
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2015
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313587/
https://ncbi.nlm.nih.gov/pubmed/25698969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00008
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