Rapid Sequencing of the Mycobacterium tuberculosis pncA Gene for Detection of Pyrazinamide Susceptibility

We developed a pyrazinamidase gene DNA-sequencing method to rapidly identify pyrazinamide resistance-causing mutations in GenoLyse-treated, smear-positive sputum specimens. The sensitivity and specificity were 90.9 and 100%, respectively, compared to those of MGIT drug susceptibility testing, after...

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Veröffentlicht in:J Clin Microbiol
Hauptverfasser: Streicher, Elizabeth M., Maharaj, Kashmeel, York, Talita, Van Heerden, Carel, Barnard, Marinus, Diacon, Andreas, Mendel, Carl M., Bosman, Marlein E., Hepple, Juli A., Pym, Alexander S., Warren, Robin M., van Helden, Paul D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Mycobacteriology and Aerobic Actinomycetes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313251/
https://ncbi.nlm.nih.gov/pubmed/25165081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.02438-14
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