Rapid Sequencing of the Mycobacterium tuberculosis pncA Gene for Detection of Pyrazinamide Susceptibility

We developed a pyrazinamidase gene DNA-sequencing method to rapidly identify pyrazinamide resistance-causing mutations in GenoLyse-treated, smear-positive sputum specimens. The sensitivity and specificity were 90.9 and 100%, respectively, compared to those of MGIT drug susceptibility testing, after...

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Vydáno v:J Clin Microbiol
Hlavní autoři: Streicher, Elizabeth M., Maharaj, Kashmeel, York, Talita, Van Heerden, Carel, Barnard, Marinus, Diacon, Andreas, Mendel, Carl M., Bosman, Marlein E., Hepple, Juli A., Pym, Alexander S., Warren, Robin M., van Helden, Paul D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Mycobacteriology and Aerobic Actinomycetes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313251/
https://ncbi.nlm.nih.gov/pubmed/25165081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.02438-14
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