Rapid Sequencing of the Mycobacterium tuberculosis pncA Gene for Detection of Pyrazinamide Susceptibility

We developed a pyrazinamidase gene DNA-sequencing method to rapidly identify pyrazinamide resistance-causing mutations in GenoLyse-treated, smear-positive sputum specimens. The sensitivity and specificity were 90.9 and 100%, respectively, compared to those of MGIT drug susceptibility testing, after...

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Detaylı Bibliyografya
Yayımlandı:J Clin Microbiol
Asıl Yazarlar: Streicher, Elizabeth M., Maharaj, Kashmeel, York, Talita, Van Heerden, Carel, Barnard, Marinus, Diacon, Andreas, Mendel, Carl M., Bosman, Marlein E., Hepple, Juli A., Pym, Alexander S., Warren, Robin M., van Helden, Paul D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2014
Konular:
Mycobacteriology and Aerobic Actinomycetes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313251/
https://ncbi.nlm.nih.gov/pubmed/25165081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.02438-14
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