Validation of pncA Gene Sequencing in Combination with the Mycobacterial Growth Indicator Tube Method To Test Susceptibility of Mycobacterium tuberculosis to Pyrazinamide

Pyrazinamide is important in the treatment of tuberculosis. Unfortunately, the diagnosis of pyrazinamide resistance is hampered by technical difficulties. We hypothesized that mutation analysis combined with the mycobacterial growth indicator tube (MGIT) phenotypic method would be a good predictor o...

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Autors principals: Simons, Sami O., van Ingen, Jakko, van der Laan, Tridia, Mulder, Arnout, Dekhuijzen, P. N. Richard, Boeree, Martin J., van Soolingen, Dick
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Mycobacteriology and Aerobic Actinomycetes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264162/
https://ncbi.nlm.nih.gov/pubmed/22090409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.05435-11
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