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Conditional disruption of miR17-92 cluster in collagen type I-producing osteoblasts results in reduced periosteal bone formation and bone anabolic response to exercise
In this study, we evaluated the role of the microRNA (miR)17-92 cluster in osteoblast lineage cells using a Cre-loxP approach in which Cre expression is driven by the entire regulatory region of the type I collagen α2 gene. Conditional knockout (cKO) mice showed a 13–34% reduction in total body bone...
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| Publicat a: | Physiol Genomics |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Physiological Society
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4313069/ https://ncbi.nlm.nih.gov/pubmed/25492928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00107.2014 |
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