Conditional disruption of miR17-92 cluster in collagen type I-producing osteoblasts results in reduced periosteal bone formation and bone anabolic response to exercise

In this study, we evaluated the role of the microRNA (miR)17-92 cluster in osteoblast lineage cells using a Cre-loxP approach in which Cre expression is driven by the entire regulatory region of the type I collagen α2 gene. Conditional knockout (cKO) mice showed a 13–34% reduction in total body bone...

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Vydáno v:Physiol Genomics
Hlavní autoři: Mohan, Subburaman, Wergedal, Jon E., Das, Subhashri, Kesavan, Chandrasekhar
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2014
Témata:
microRNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313069/
https://ncbi.nlm.nih.gov/pubmed/25492928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00107.2014
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