Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

Aiming towards the development of novel nootropic therapeutics to address the cognitive impairment common to a range of brain disorders, we set out to develop highly selective small molecule inhibitors of HDAC2, a chromatin modifying histone deacetylase implicated in memory formation and synaptic pl...

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Detalles Bibliográficos
Publicado en:Chem Sci
Main Authors: Wagner, F. F., Zhang, Y.-L., Fass, D. M., Joseph, N., Gale, J. P., Weïwer, M., McCarren, P., Fisher, S. L., Kaya, T., Zhao, W.-N., Reis, S. A., Hennig, K. M., Thomas, M., Lemercier, B. C., Lewis, M. C., Guan, J. S., Moyer, M. P., Scolnick, E., Haggarty, S. J., Tsai, L.-H., Holson, E. B.
Formato: Artigo
Idioma:Inglês
Publicado: Royal Society of Chemistry 2015
Assuntos:
Chemistry
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310013/
https://ncbi.nlm.nih.gov/pubmed/25642316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc02130d
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