Murine Pancreatic Adenocarcinoma Reduces Ikaros Expression and Disrupts T Cell Homeostasis

BACKGROUND: Maintenance of T cell immune homeostasis is critical for adequate anti-tumor immunity. The transcription factor Ikaros is essential for lymphocyte development including T cells. Alterations in Ikaros expression occur in blood malignancies in humans and mice. In this study, we investigate...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nelson, Nadine, Xiang, Shengyan, Zhang, Xiaohong, Gilvary, Danielle, Djeu, Julie, Husain, Kazim, Malafa, Mokenge, Vohra, Nasreen, Pilon-Thomas, Shari, Ghansah, Tomar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309586/
https://ncbi.nlm.nih.gov/pubmed/25629611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115546
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